MEGABIOTIC® 100 Billion Friends in a Capsule

The prebiotic Isomalto-oligosaccharides is derived from starch and serves as food for probiotic bacteria, supporting their growth and activity in the colon.

The digestive enzyme blend contains naturally occurring enzymes such as Amylase, Lactase, Lipase, Protease and Papain, extracted from plant or microbial sources. These enzymes specialize in breaking down carbohydrates, proteins, fats and fibers, facilitating the efficient absorption of nutrients from food.

CFUs, or colony-forming units, represent the number of live bacteria in a probiotic product that are able to multiply and form colonies. This measure indicates the number of active probiotic bacteria present in a dose and their ability to colonize the gut.

Why is a concentration of 100 billion CFU important?

• Rapid gut repopulation: a dose of 100 billion CFU helps to quickly restore the gut microbiome affected by factors such as diet and antibiotics.
• Survival in the digestive tract: the high concentration and gastro-resistant capsule ensure that a sufficient number of natural probiotics reach the colon, where they can colonize effectively.
• Long-term benefits: high concentrations support digestion, reduce inflammation and strengthen immunity, contributing to the overall health of the body.

One capsule – triple solution for the health of the whole body

This formulation with three main components is adapted to the current demands of consumers, who are looking for effective, convenient solutions with multiple health benefits.

1. High concentration of Probiotics:
   • MEGABIOTIC® contains 100 billion colony-forming units (CFU) per capsule, a higher concentration than many other products on the market, ensuring a rapid and efficient repopulation of the intestinal flora. This positions it as a premium supplement, intended both for those who want to maintain their intestinal health daily, and for people with special digestive needs.
2. Enteric capsule – protection and efficiency:
   • The enteric capsule protects sensitive ingredients from stomach acidity, allowing probiotics and digestive enzymes to reach the intestines directly. This aspect not only increases the effectiveness of the product, but also differentiates MEGABIOTIC® on the market, given that many competitors offer standard capsules, which can reduce the viability of probiotic bacteria.
3. Synergistic formula: Probiotics, Prebiotics and Digestive Enzymes:
   • This triple combination supports not only intestinal health, but also the immune system and the efficient absorption of nutrients. Prebiotics provide a nutritional substrate for probiotics, optimizing their effects in the colon. Digestive enzymes, on the other hand, contribute to the efficient breakdown of nutrients and the reduction of digestive discomfort. MEGABIOTIC® is thus a complete product that can replace several different supplements.
4. According tot for responsible consumers:
   • MEGABIOTIC® is formulated without dyes, preservatives, artificial flavors, gluten or animal ingredients, making it suitable for vegetarians and attractive to consumers who prefer clean products from natural sources.

The premium supplement for digestive and immune health

MEGABIOTIC® is aimed at those looking for advanced solutions with multiple benefits for their digestive and immune health. Compared to standard products that may contain only probiotics, probiotics and prebiotics or only digestive enzymes, MEGABIOTIC® offers a complete package. Its effectiveness is supported by the high concentration of natural probiotics and the enteric capsule, which improves the efficiency of administration.

How do they work?

Probiotics work according to the specific characteristics of each strain, which allow them to survive and colonize different areas of the body, such as the small intestine, colon or vagina, depending on their sensitivity to pH and their ability to attach to specific mucosa. They respond to chemical signals in the environment and interact with the immune system, producing compounds that inhibit pathogens, support local health and help maintain a balanced microbiome.

What are probiotics?

Probiotics are live microorganisms, generally bacteria and sometimes yeasts, which, when consumed in adequate amounts, provide health benefits, especially for the digestive system. They help maintain the balance of intestinal flora, preventing the proliferation of harmful bacteria. Probiotics also contribute to strengthening the immune system, producing vitamins and improving the absorption of nutrients.

MEGABIOTIC® includes a selection of probiotic strains from the Lactobacillus and Bifidobacterium genera, the most studied and used in probiotics due to their benefits for digestive health. In addition, the formula also contains other important natural probiotic genera, such as Streptococcus, Saccharomyces (probiotic yeasts), Enterococcus and Bacillus, offering a broad spectrum of action supported by scientific research that continues to identify new strains valuable for overall health.

• Lactobacillus: these bacteria are naturally found in the small intestine and genital tract. They contribute to the breakdown of lactose and the production of lactic acid, which inhibits the growth of pathogenic bacteria.

• Bifidobacterium: these bacteria are found in the large intestine, contributing to the breakdown of fiber and maintaining an acidic environment, which prevents the proliferation of harmful microorganisms.
• Saccharomyces boulardii: a probiotic yeast, effective in combating diarrhea and maintaining intestinal health.
• Streptococcus: includes strains such as Streptococcus thermophilus, frequently used in yogurt production, but also for its benefits on gastrointestinal health.
• Saccharomyces: for example, Saccharomyces boulardii, a probiotic yeast used to support intestinal health and prevent diarrhea.
• Bacillus: includes strains such as Bacillus coagulans, which is resistant to acidic environments and can survive in the digestive tract.
• Enterococcus: includes strains such as Enterococcus faecium, used in some probiotic supplements for gut health.

Did you know?
There are over 500 scientifically documented strains of probiotics in total, and research continues to uncover new strains and explore their potential health benefits.

History of Probiotics

Probiotics have a long history, with their intuitive use existing long before they were scientifically understood:

Antiquity: The consumption of fermented foods dates back thousands of years, being practiced by various ancient cultures. For example, yogurt, kefir, kimchi, and pickles were consumed in the Middle East and Asia, and their consumption was associated with health and longevity.

20th century:

• In 1907, Elie Metchnikoff, a Russian biologist and Nobel Prize winner, introduced the concept of probiotics. He observed that rural Bulgarians who regularly consumed fermented yogurt had a longer lifespan. Metchnikoff suggested that the lactic acid bacteria in yogurt might prolong life by inhibiting the growth of harmful bacteria in the gut.
• During the same period, Henry Tissier at the Pasteur Institute in France discovered bacteriaBifidobacterium ile in the feces of breastfed infants. He suggested that these bacteria could help improve digestion and treat diarrhea.

1930s-1970s:

• In Japan, in the 1930s, a probiotic drink called Yakult was developed, which contained the bacteria Lactobacillus casei Shirota. This was one of the first commercially available probiotic drinks to achieve widespread success.
• In the 1960s, the term “probiotic” began to be used to describe beneficial microorganisms, as distinct from antibiotics, which kill bacteria.

1980s–present:

• In the 1980s and 1990s, research on probiotics intensified, with numerous studies published on their effects on digestive and immune health.
• Today, probiotics are widely recognized for their health benefits and are included in supplements, yogurts, beverages, and functional foods. Probiotics are being studied for their potential benefits in preventing and treating various conditions, such as irritable bowel syndrome, antibiotic-associated diarrhea, urinary tract infections, and allergies.

Why do we need probiotics?

Probiotics have beneficial effects on many organs and systems in the body, not just the digestive tract. Here are the main organs and systems influenced by probiotics:

1. Intestines

Probiotics are especially known for their effect on intestinal health. They help balance the intestinal microbiome and contribute to:

• Preventing diarrhea, including that caused by antibiotics.
• Reducing symptoms of irritable bowel syndrome and other gastrointestinal disorders.
• Improving the absorption of nutrients, such as vitamins and minerals.
• Stimulating the production of short-chain fatty acids, which are essential for colon health and preventing intestinal inflammation.

2. Immune System

Probiotics play a significant role in stimulating the immune system. They help to:

• improve the immune response by stimulating the production of antibodies and immune cells (such as T lymphocytes).
• Reduce chronic inflammation by regulating immune system reactions.
• Prevent respiratory and other infections by improving the body’s defenses.

3. Brain

There is a bidirectional connection between the gut and the brain, known as the “gut-brain axis.” Probiotics can influence mental health and cognitive function by:

• Reduce symptoms of anxiety and depression. Some natural probiotics (also called “psychobiotics”) produce happiness and satisfaction neurotransmitters involved in the reward process and in creating feelings of happiness and satisfaction after performing certain activities.
• improving sleep quality through their effects on hormonal balance and stress reduction.

4. Skin

Probiotics may have positive effects on the skin, due to their role in reducing inflammation and balancing the microbiome:

• Help reduce symptoms of acne, eczema, and rosacea by reducing inflammation and immune response.
• Support overall skin health, contributing to hydration and protection against harmful bacteria.
• Improving wound healing and skin regeneration.

5. Oral Cavity

Probiotics help balance the oral microbiome and reduce harmful bacteria, with benefits for:

• Reducing the risk of tooth decay and gingivitis.
• Improving gum health and reducing plaque.
• Improving breath and preventing halitosis (bad breath).

6. Vagina and Urogenital Tract

Probiotics can help maintain the balance of vaginal bacterial flora, being beneficial for urogenital health:

• They prevent vaginal infections, such as bacterial vaginosis and candidiasis, by maintaining a healthy pH and inhibiting the growth of pathogenic microorganisms.
• They help prevent urinary tract infections by fighting pathogenic bacteria that can colonize the urinary tract.

7. Liver

Probiotics can have a protective effect on the liver by reducing inflammation and toxicity:

• Helps reduce liver burden by preventing the absorption of toxins from the intestine.
• May help reduce liver fat levels and prevent liver diseases, such as non-alcoholic fatty liver disease.

Ingredients and Benefits

1. Probiotics (500 billion CFU/gram, providing 100 billion CFU per capsule)

Each strain in the product is carefully selected to support digestive and immune health:

• Lactobacillus acidophilus: supports lactose digestion, reduces symptoms of irritable bowel syndrome and helps maintain a healthy microbiome.
• Levilactobacillus brevis: promotes gastrointestinal health and helps reduce inflammation.
• Lacticaseibacillus casei: supports immune health and improves digestion.
• Lactobacillus crispatus: supports vaginal bacterial balance and prevents infections.
• Limosilactobacillus fermentum: provides protection against pathogens and helps support the immune system.
• Lactobacillus gasseri: supports weight management and gut health.
• Lactobacillus helveticus: helps reduce anxiety and supports bone health.
• Lactobacillus jensenii: supports vaginal health and helps prevent infections.
• Lactobacillus johnsonii: helps maintain skin health and supports immunity.
• Lacticaseibacillus paracasei: supports respiratory health and immunity.
• Lactiplantibacillus plantarum: helps prevent bloating and improves digestion.
• Limosilactobacillus reuteri: supports digestive health and maintains oral health.
• Lacticaseibacillus rhamnosus: reduces the risk of gut infections and supports immune health.
• Latilactobacillus sakei: helps balance the gut microbiome.
• Ligilactobacillus salivarius: maintains oral health and contributes to digestion.
• Lactobacillus delbrueckii subsp. Bulgaricus: supports lactose digestion.
• Lactococcus lactis subsp. Lactis: provides protection against pathogenic bacteria.
• Leuconostoc mesenteroides subsp. Mesenteroides: supports skin health and improves digestion.
• Bifidobacterium adolescentis: promotes digestive health and reduces inflammation.
• Bifidobacterium animalis subsp. Animalis: Supports immunity and gut health.
• Bifidobacterium bifidum: Helps improve digestion and reduce inflammation.
• Bifidobacterium breve: Supports digestive health and reduces gut inflammation.
• Bifidobacterium longum subsp. Infantis: Helps with digestion and supports brain health.
• Bifidobacterium animalis subsp. Lactis: Improves immune and digestive health.
• Bifidobacterium longum subsp. Longum: Supports gut health and reduces inflammation.
• Pediococcus cidilactici: Protects against pathogens and supports digestive health.
• Streptococcus salivarius subsp. Thermophilus: contributes to lactose digestion and supports immunity.

2. Prebiotics – Isomalto-oligosaccharides (150 mg)

Prebiotics are fibers that feed natural probiotics in the colon, helping to maintain intestinal health.

What are Isomalto-oligosaccharides?

Isomalto-oligosaccharides (IMO) are prebiotic fibers obtained mainly from starch (usually from corn, tapioca or potatoes). These are complex carbohydrates that are not completely digested by the human digestive system, thus reaching the colon, where they serve as food for beneficial bacteria (probiotics) in the intestine.

Characteristics and Properties

• Type of prebiotic: IMOs are recognized for their beneficial effects on intestinal flora, as they support the growth of beneficial bacteria, such as Bifidobacterium and Lactobacillus.
• Slightly sweet taste: Isomalto-oligosaccharides have a slightly sweet taste and are often used as a natural sweetener in low-calorie foods and supplements.
• Low glycemic index: Unlike sugars, IMOs have a low impact on blood glucose levels, making them suitable for people with diabetes or those following a low-carb diet.

Isomalto-oligosaccharides (IMO) support intestinal health by stimulating beneficial bacteria, supporting immunity and reducing inflammation, helping to maintain a healthy gut.healthy levels of sugar and cholesterol in the blood and contributes to regular bowel transit, preventing constipation.

3. Digestive Enzymes (20 mg)

Digestive enzymes help break down nutrients in food into smaller, easily absorbable compounds. MEGABIOTIC® contains the following enzymes:

• Amylase: Breaks down starch into simple sugars.
• Glucoamylase: Converts complex sugars into simple sugars.
• Cellulase: Breaks down cellulose fibers, supporting the digestion of plant fibers.
• Hemicellulase: Helps break down hemicellulose.
• Beta-glucanase: Contributes to the digestion of cereal fibers.
• Xylanase: Supports the digestion of plant fibers.
• Pectinase: Helps break down pectin in fruits.
• Lactase: Facilitates the digestion of lactose, reducing the symptoms of lactose intolerance.
• Phytase: Helps absorb minerals by breaking down phytic acid.
• Lipase: Breaks down fats into fatty acids.
• Protease: Contributes to the digestion of proteins.
• Acid Protease: Helps to efficiently break down proteins into amino acids.
• Papain: Proteolytic enzyme from papaya, contributes to the breakdown of proteins.

How does MEGABIOTIC® help you?

Consuming an effective blend of probiotic and prebiotic strains with digestive enzymes brings numerous benefits for digestive and immune health.

Benefits of Multiple Probiotic Strains

1. Covering a Wide Range of Benefits: Each probiotic strain supports health in unique ways. For example, lactobacillus acidophilus improves lactose digestion, and bifidobacterium lactis can boost immunity. A blend of strains offers benefits on multiple fronts, such as digestion, immunity, and reducing inflammation.
2. Restore and balance the gut microbiome: The gut microbiome is extremely diverse. A blend of probiotic strains helps restore this balance by increasing the diversity of gut flora, essential for optimal digestive health and preventing chronic diseases.
3. Synergistic effect: Certain combinations of probiotics, such as lactobacillus and bifidobacterium, work synergistically to enhance overall benefits, such as reducing inflammation and improving symptoms of irritable bowel syndrome.
4. Solving multiple digestive problems: Each probiotic strain can treat specific digestive symptoms. For example, lactobacillus rhamnosus can reduce diarrhea, while bifidobacterium longum helps combat constipation.
5. Support for the immune system and preventing infections: Various probiotic strains, such as lactobacillus reuteri and bifidobacterium bifidum, boost immunity and reduce the risk of bacterial and viral infections.
6. Flexibility and resistance to environmental changes: Different strains can better tolerate pH variations and conditions in the digestive tract, increasing their chances of survival and efficiency throughout the digestive system.
7. Faster recovery and resistance to factors adversi: after antibiotic treatments, a diverse mix of natural probiotics can accelerate the restoration of the microbiome and reduce the negative effects of antibiotics on the intestinal flora.
8. Reducing the risk of pathogen colonization: multiple probiotic strains can inhibit the development of pathogens by competing for nutrients and producing organic acids, supporting intestinal health.

Why is it good to consume probiotics with prebiotics and digestive enzymes?

Prebiotics are non-digestible fibers that feed probiotic bacteria in the intestine, helping to support and multiply them. Consuming probiotics with prebiotics (symbiosis) provides an optimal environment for beneficial bacteria, allowing them to effectively colonize the intestine and contribute to balancing the intestinal flora. Benefits include:

1. Supporting the Growth and Activity of Probiotics: Prebiotics, such as Isomalto-oligosaccharides, feed probiotics, supporting their activity and thus increasing their efficiency.
2. Improving Intestinal Transit: Prebiotics promote healthy intestinal transit, reducing the risk of constipation and other digestive problems. Combined with probiotics, they can support optimal digestion.

Digestive enzymes help break down the macronutrients in food – proteins, fats and carbohydrates – into smaller, more easily absorbable compounds. Consuming them together with probiotics and prebiotics brings the following benefits:

1. improved Nutrient Bioavailability: Digestive enzymes ensure the efficient breakdown of food, facilitating maximum nutrient absorption. at the same time, probiotics contribute to a healthy microbiome, which helps with the absorption of certain vitamins and minerals.
2. Reducing Bloating and Digestive Discomfort: Digestive enzymes reduce stress on the digestive system by breaking down food, and probiotics balance the intestinal flora, which helps reduce gas and bloating.
3. Supporting Overall Health: together, probiotics, prebiotics, and digestive enzymes create a complete digestive and immune support system, with complementary roles that promote healthy digestion, regular bowel movements, and better overall health.

Why choose an enteric-coated probiotic?

An enteric capsule is considered more efficient for administering probiotics and digestive enzymes for several reasons:

1. Protection against stomach acid

• Probiotics and many digestive enzymes are sensitive to the acidic environment of the stomach, where stomach acid can destroy or inactivate them before they reach the intestine, where they can exert their beneficial effects. Enteric capsules are designed to withstand the acidity of the stomach, releasing the contents only in the intestines, where the pH is more suitable for their survival and activation.

2. More efficient absorption

• Enteric capsules ensure a controlled and targeted release of the active ingredients, allowing probiotics and enzymes to reach where they are most needed – in the small intestine and colon. This specific release maximizes absorption and effectiveness, so that the body benefits more from the action of these supplements.

3. Delayed and controlled release

• Enteric capsules are designed to release ingredients in a controlled manner, usually depending on the pH of the intestine. This means that the probiotics and digestive enzymes are released gradually, ensuring a constant presence in the intestine and providing long-term benefits.

4. Ensuring the viability of probiotics

• Probiotics are living organisms, and exposure to the high acidity of the stomach can kill a significant part of the beneficial bacteria before they reach the colon. Enteric capsules provide additional protection, allowing probiotics to survive gastric transit and reach their destination intact, where they can colonize and balance the intestinal microbiome.

5. Reduction of side effects

• By avoiding rapid decomposition in the stomach, enteric capsules can reduce the risk of gastric discomfort, bloating and other unpleasant side effects. In the case of probiotics, this is important, as they can produce gas during digestion, and enteric capsules can minimize this impact in the stomach.