Known as vitamin B9, folic acid is a vital element within the B vitamin complex, indispensable for the health of the body.
As a water-soluble vitamin, it performs essential functions, such as participating in the production of red blood cells, synthesizing DNA and supporting the proper neurological development of the fetus.
Folic Acid – Vitamin B9 is found in two main forms:
- folate, naturally present in foods.
- folic acid, the synthesized version used in dietary supplements and fortified foods.
Quatrefolic®, folate in its natural form, provides a bioactive and natural version of vitamin B9, which is fundamental for a multitude of biological processes. Quatrefolic® facilitates energy generation, efficient nutrient metabolism and supports nervous system function.
Folic Acid Vs. Folate Quatrefolic®
Although the terms “folic acid” and “folate” are often confused, there is a clear difference between the two.
Folate, the natural form of vitamin B9, is found in green vegetables, citrus fruits, beans and lentils, and is directly usable by the body, unlike folic acid, its synthetic version, which requires its transformation before it can be used.
Natural folates from foods are also present in some supplements, but require conversion to the active form of folate, unlike versions like Quatrefolic®, which are already active and ready to use.
What is Folic Acid?
Folic acid is the synthetic form of vitamin B9, vital for the creation of DNA and RNA, essential for the formation of new cells and the maintenance of existing ones, including red blood cells. It is particularly important in the prevention of birth defects, due to its role in fetal development.
Recommended doses of folic acid vary depending on age, sex and specific conditions, such as pregnancy or certain medical conditions. Pregnant women and those planning a pregnancy are encouraged to consume 600-800 μg/day to prevent neural tube defects in the fetus.
What is Quatrefolic®?
Folic Acid Quatrefolic® from COSMO PHARM® is an innovative supplement designed to function as a nutrient in all conditions in which folic acid and its supplementation have been recommended.
Quatrefolic® is the glucosamine salt of (6S)-5-methyltetrahydrofolate and is structurally analogous to the active form of folic acid. Developed by Gnosis By Lesaffre, it represents the fourth generation of folate compared to the calcium salt of 5-methyltetrahydrofolate, guaranteeing improved bioavailability.
Folate in the form of 5-methyltetrahydrofolate (5-MTHF) is considered superior to folic acid due to significant key advantages, which make it recommended and preferred in vitamin B9 supplementation:
- Immediate bioavailability: 5-MTHF is ready to use as soon as it enters the body, without requiring complex conversions like folic acid.
- Avoiding the problem of MTHFR polymorphism: 5-MTHF reaches directly to those who cannot process folic acid well due to genetic variations, ensuring access to the necessary folate.
- Reducing the risk of accumulation of unmetabolized folic acid:The use of 5-MTHF helps prevent the health risks associated with excess unmetabolized folic acid in the body.
- Effective in managing homocysteine: 5-MTHF converts more efficiently homocysteine into methionine, supporting heart health without additional steps.
- Brain benefits: 5-MTHF directly supports brain health and mood, making it ideal for the elderly or those at risk of cognitive decline.
- Pregnancy support: 5-MTHF provides the most effective form of folate to prevent neural tube defects and support healthy fetal development.
Therefore, active folates like Quatrefolic® help prevent problems associated with excess accumulation of synthetic folic acid in the body, such as cognitive decline and increased risk of congenital diseases or tumors.
Why choose Quatrefolic® from COSMO PHARM®?
Here’s why Quatrefolic® Folic Acid stands out as your trusted source for quality folate, easily absorbed by the body:
- Direct access to the active form: with quatrefolic®, you receive directly 5-methyltetrahydrofolate, the active and ready-to-act form of folate, naturally present in your body.
- Certified safety: we have the GRAS (Generally Recognized As Safe) seal, a clear sign that we care about your health. Preclinical and clinical studies guarantee the quality of Quatrefolic®.
- Protected innovation: We not only have the innovation, but also its protection through patents, ensuring that you benefit from the latest discoveries in the field of folate.
- Guaranteed quality: Quatrefolic® production complies with the highest GMP (Good Manufacturing Practices) standards, promising you a product of consistent quality, every time you choose Quatrefolic® Folic Acid from COSMO PHARM®.
- Vegetarian-friendly: The glucosamine in Quatrefolic® does not come from animal sources, making it friendly for vegetarians or anyone looking for ethical alternatives in supplement administration.
- Superior bioavailability: Compared to alternatives, Quatrefolic® Folic Acid demonstrates its superiority through improved water solubility and higher bioavailability big.
When should I take folic acid?
Folic acid administration is particularly indicated in cases of deficiency or during pregnancy:
- Folic Acid Deficiency
Folic acid deficiency can be caused by: inadequate nutrition, digestive disorders, excessive alcohol consumption, the use of certain medications or specific conditions, such as pregnancy. Symptoms can include anemia, difficulty concentrating, growth problems, nervousness, palpitations, skin and hair problems, headaches and digestive disorders.
- Folic acid during pregnancy:
Folic acid is crucial for pregnant women, reducing the risk of birth defects and supporting a healthy pregnancy.
Leading health bodies, including the European Food Safety Authority (EFSA) and the US Food and Drug Administration (FDA), recommend folate through dietary supplements, folic acid, or folate from foods in the weeks before conception to prevent neural tube defects (birth defects affecting the brain, spine, or spinal cord).
During pregnancy, women’s folate needs increase significantly, reaching levels 5-10 times higher to support the rapid processes of cell synthesis, growth, division, and DNA repair that occur in the developing embryo. According to FDA recommendations, this translates to a daily requirement of 400 to 800 micrograms of folic acid.
People with genetic variations of the MTHFR enzyme cannot process folic acid efficiently, making active forms of folate, such as Quatrefolic®, increasingly preferred options for supplementation globally.
Specialist’s recommendation:
Specialists recommend combining folic acid with omega-3 fatty acids with high concentrations of EPA and DHA such as Mega Omega 3 Fish Oil with 432 EPA and 288 DHA for the health of the mother and fetus, contributing especially to the brain development of the fetus.
Folic Acid Benefits:
Pregnancy. Deficiency. Cardiovascular system. Immunity.
- It has a favorable effect on a normal pregnancy, being essential in the healthy development of the fetus and in the prevention of neural tube defects (spina bifida and anencephaly, in newborns).
- It helps prevent pregnancy complications, such as preeclampsia, protecting both the health of the mother and the fetus.
- It helps combat folate deficiency which can lead to megaloblastic anemia, congenital problems, mental disorders, and a weakened immune system.
- It contributes to the health of the heart and blood vessels, by reducing levels of homocysteine, an amino acid associated with an increased risk of heart disease.
- It contributes to the formation of new cells, including red blood cells, vital for a strong immune system.
Health of the nervous system
- Supports the proper functioning of nervous system and can prevent neurological and emotional development disorders.
- Folic acid can improve mood and help fight depression.
- Contributes to the process of cell division.
- Contributes to maintaining concentration and alertness.
- Quatrefolic® folic acid is necessary for mental function and performance.
- Contributes to protecting vision.
Indicated in:
- pregnancy, infertility, anemia, megaloblastic anemia, depressive states, memory problems, allergies,
- muscle weakness, difficulty concentrating, growth problems, nervousness, palpitations,
- skin and hair problems, digestive disorders.
Contraindications and Precautions:
Contraindications include conditions such as liver cirrhosis, certain hematological disorders, anticonvulsant treatments, history of colorectal cancer, and intolerance or allergy to folic acid.
Dose:
Adults: 1 vegetable capsule per day. Or as recommended by a healthcare professional.
Does not contain: colorings, preservatives, artificial flavors, sugar, sodium, gluten/wheat, shellfish/fish, eggs, peanuts/nuts, soy, lactose.
Product combinations:
Magnesium 375+ Vitamin b6: together with folic acid, vitamin b6 helps reduce homocysteine levels, a risk factor for cardiovascular disease.
Iron + Vitamin C Duo Liposomal: for pregnant women or people with anemia, combining folic acid with iron can help prevent anemia. Iron supports the formation of red blood cells, while folic acid helps produce DNA necessary for the formation of new cells.
MegaOmega 3: supplementation with folic acid and omega-3 fatty acids may provide cognitive benefits and support heart health. This combination is also often recommended during pregnancy for the neurological development of the fetus.
Calcium + Vitamin D3: especially for menopausal or postmenopausal women, the combination of folic acid with calcium and vitamin d can support bone and heart health.
Zinc Bisglycinate 25 mg: zinc and folic acid are often recommended together to support fertility in men and women.
Natural Vitamin E 400 IU: the combination of folic acid with antioxidants can enhance the protective effects of each, helping to protect the body from oxidative stress and supporting cardiovascular health.
Composition
Ingredients / 1 vegetable capsule:
| Quatrefolic ((6S)5-methyltetrahydrofolate, Glucosamine salt) | 1.38 mg |
| providing 54% Folic Acid | 800 mcg |
It contains no allergens. Zero calories.
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