Zinc Bisglycinate (chelate) 25 mg high bioavailability

Zinc bisglycinate stands out as the best zinc supplement due to its improved absorption, gentle effect on the gastrointestinal system, and its effectiveness in increasing zinc levels in the body. It outperforms other forms such as zinc gluconate, zinc oxide, and even zinc picolinate in various studies.

The Role of Zinc in the Body

Zinc is indispensable for numerous biological functions:

• Immune Function: Zinc is crucial for the production of white blood cells, including natural killer (NK) cells, T-lymphocytes, and B-lymphocytes, all of which are vital for a robust immune response. Vitamin C with zinc is often recommended to support this function.
• Hormon production: Adequate levels of zinc are necessary to maintain healthy levels of male hormones.
• Skin health and wound healing: Zinc supports skin integrity and accelerates wound healing processes. Zinc oxide cream is frequently used for its protective and healing properties.
• Eye health: Zinc is essential for eye health, especially for the macula, which is the central part of the retina.
• Growth and development: Zinc is necessary for normal growth and development, especially during pregnancy, childhood, and adolescence. Zinc for children is essential during this period.
• Taste and smell: Zinc is necessary for maintaining the senses of taste and smell.
• Mineral absorption: Zinc plays a role in the absorption and metabolism of other minerals. Supplements containing calcium magnesium zinc selenium are useful for ensuring an adequate mineral balance.

Zinc Bisglycinate: what it is and why it is effective

Zinc bisglycinate is a chelated form of zinc in which one zinc atom is bound to two molecules of the amino acid glycine. This chelation improves its stability and absorption. The term “bis” refers to the two glycine molecules, hence the name bisglycinate.

Benefits of Zinc Bisglycinate

1. Superior Absorption:

Research indicates that zinc bisglycinate has superior absorption compared to other forms of zinc, such as zinc gluconate and zinc oxide. The chelation process allows zinc bisglycinate to be absorbed intact in the small intestine, without competing with other minerals.

1. Gentle on the Stomach:

Zinc bisglycinate is known for being gentle on the gastrointestinal tract, reducing the risk of nausea and other gastrointestinal symptoms often associated with zinc supplements.

1. Effective in Deficiency:

Due to its high absorption rate, zinc bisglycinate is particularly effective in correcting zinc deficiencies and ensuring adequate zinc levels in the body.

Comparing zinc bisglycinate to other forms of zinc

Zinc Picolinate

Zinc picolinate is another well-known form of zinc in which zinc is bound to picolinic acid. This form is also recognized for its high bioavailability and efficacy.

• Absorption: Zinc picolinate is very well absorbed and effective in increasing zinc levels in the body.
• Uses: It is commonly used to support immune function, skin health, and general well-being.

Zinc Gluconate

Zinc gluconate is a form of zinc bound to gluconic acid and is widely available in dietary supplements.

• Absorption: Zinc gluconate is reasonably well absorbed, although not as effectively as zinc bisglycinate or picolinate.
• Uses: It is often used in lozenges to help reduce the duration of cold symptoms.

Zinc Oxide

Zinc oxide is an inorganic form of zinc commonly used in topical applications, such as sunscreens and diaper rash creams.

• Absorption: Zinc oxide has poor absorption when taken orally compared to other forms of zinc.
• Uses: It is primarily used for its protective and anti-inflammatory properties in skin care products.

Factors that affect zinc absorption

Zinc absorption can be influenced by various dietary, lifestyle, and health factors.te:

1. Phytates: Found in staple foods such as cereals, corn and rice, phytates can strongly inhibit zinc absorption by binding to zinc and forming insoluble complexes.
2. Oxalates: Found in foods such as spinach and black tea, oxalates can also inhibit zinc absorption.
3. Dietary competitors: High doses of iron and calcium can compete with zinc for absorption in the intestines. Therefore, zinc supplements should be taken with caution.
4. Medications: Certain medications, including antacids and acid-blocking medications, can reduce zinc absorption by altering stomach acidity.
5. Health Conditions: Gastrointestinal disorders such as Crohn’s disease and celiac disease can impair zinc absorption and increase the risk of deficiency.

Research on Zinc Bisglycinate

Several studies have shown superior absorption and efficacy of zinc bisglycinate compared to other forms of zinc.

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One study compared the oral bioavailability of zinc bisglycinate with zinc gluconate in twelve healthy female volunteers (both products were administered orally at a single dose of 15 mg (7.5 mg x 2), with a 7-day wash-out period between the two tests). The study showed that zinc bis-glycinate, a new formulation, had a significantly higher bioavailability (+43.4%) compared to zinc gluconate. The administration of zinc bis-glycinate was safe and well tolerated.
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Gandia P, Bour D, Maurette JM, Donazzolo Y, Duchène P, Béjot M, Houin G. A bioavailability study comparing two oral formulations containing zinc (Zn bis-glycinate vs. Zn gluconate) after a single administration to twelve healthy female volunteers. Int J Vitam Nutr Res. 2007 Jul;77(4):243-8. doi: 10.1024/0300-9831.77.4.243. PMID: 18271278.

Study 1: Comparative Absorption

A small crossover study involving 12 healthy volunteers compared the absorption of 15 mg of zinc in the form of bisglycinate versus zinc gluconate. The results showed that zinc bisglycinate led to increases in blood zinc levels that were 43% greater than zinc gluconate, demonstrating its superior absorption.

Study 2: Increased Blood Zinc Levels

In another study, 30 healthy women were divided into three groups: one group took 60 mg of zinc bisglycinate, another took 60 mg of zinc gluconate, and the third group took a placebo. Over six weeks, the zinc bisglycinate group showed significant increases in blood zinc levels, while the zinc gluconate group did not show consistent increases.

Study 3: Single-dose absorption

A study in 12 healthy women compared single doses of zinc bisglycinate, zinc picolinate, zinc gluconate, and zinc oxide. Zinc bisglycinate resulted in the highest plasma zinc levels, and red blood cell zinc levels followed the order: zinc bisglycinate > zinc picolinate > zinc gluconate > zinc oxide.

Who is Zinc Bisglycinate indicated for?

Zinc Bisglycinate is indicated for various groups of people, including:

• People with digestive disorders: such as Crohn’s disease, ulcerative colitis or malabsorption syndrome, who may have difficulty absorbing zinc.
• Elderly people: who may have reduced zinc absorption.
• People with immune disorders: who require additional support for the immune system.
• Vegetarians: who may have a lower intake of zinc from their diet.
• Those taking:
  1. Antacids
  2. Iron, magnesium, calcium supplements above the daily requirement
  3. Treatment of metal poisoning heavy
  4. Diuretics
  5. Antibiotics – Tetracycline, Doxycycline
  6. Medications for the Treatment of Osteoporosis
  7. Anticonvulsant Medications
  8. Antiretroviral Medications
  9. Some medications used to treat HIV/AIDS can interfere with the absorption of zinc.

What foods contain Zinc?

• Foods rich in zinc include red meat, poultry, seafood (especially oysters), beans, nuts, seeds, dairy products, and whole grains. Regular consumption of zinc foods helps maintain adequate zinc levels in the body.

Zinc Health Benefits:

Immune Function:

• Zinc is essential for the normal functioning of the immune system.
• It helps activate T lymphocytes (cellsT) which controls and regulates immune responses and attacks infected or cancerous cells.
• Decreases susceptibility to infections.

Skin and Eye Health:

• Zinc is an important structural element for many proteins and enzymes.
• Contributes to eye health and may prevent age-related macular degeneration.
• Important for the growth and repair of tissues, including skin and hair.
• Contributes to the health of hair follicles and may prevent hair loss.
• Zinc supplementation may stimulate hair growth.
• Essential for maintaining skin integrity, preventing and improving dermatological conditions such as acne and infections, by regulating sebum production and its anti-inflammatory and antibacterial properties.
• Plays a crucial role in collagen synthesis and normal cell membrane function.
• Used in tissue repair processes and wound healing.

Fertility:

• Essential for reproductive health in both men and women.
• In men, it contributes to sperm production and maintaining healthy testosterone levels.
• In women, it helps balance hormones and is crucial for normal ovarian function.
• Plays a vital role in spermatogenesis (the process of sperm production).
• Contributes to improving male fertility.
• Helps regulate hormones and maintain hormonal balance in men and women.
• Involved in the synthesis and function of sex hormones and stress hormones.

Normal Growth and Development:

• Essential for normal growth and development of the body, being involved in cell division and DNA synthesis
• Especially important during periods of rapid growth, such as childhood and adolescence.
• Contributes to normal acid-base metabolism
• Crucial for maintaining the senses of taste and smell. Zinc deficiency can lead to the loss or alteration of these senses
• Helps in the efficient absorption and use of other minerals and nutrients in the body, contributing to overall nutritional balance
• Has antioxidant properties that help protect cells against oxidative damage caused by free radicals

• Contributes to normal acid-base, carbohydrate and fatty acid metabolism
• Supports normal protein synthesis
• Maintains normal vitamin A metabolism
• Contributes to normal cognitive function
• Supports normal DNA synthesis and the process of cell division
• Contributes to the protection of cells against oxidative stress

Contraindications:

For those considering zinc supplementation, consultation with a healthcare provider is recommended to determine the appropriate form and dosage based on individual health needs and existing conditions. It is also important to be aware of zinc contraindications and discuss any concerns with a healthcare professional.

High doses of zinc can cause nausea, vomiting, diarrhea, and abdominal pain. These symptoms are common when zinc is taken on an empty stomach.

Zinc may interact with certain medications, such as antibiotics and diuretics, affecting their effectiveness.

What can it be combined with?

Zinc can be combined with a variety of other dietary supplements to enhance health benefits. Here are some common combinations and associated benefits:

Liposomal Vitamin C: essential for immune system function. The combination may help prevent and reduce the duration of colds and other respiratory infections. Immune-boosting supplements often contain both zinc and vitamin C.

Magnesium Bisglycinate: important for muscle and nerve function. Magnesium helps relax muscles, while zinc is essential for cell repair and protein synthesis.

Natural Marine Magnesium + Vitamin B6: supports metabolic function and brain health. Vitamin B6 helps metabolize protein and carbohydrates and supports cognitive function.

Example: zinc, magnesium and vitamin B6.

Zinc and ViVitamin D 3 2000 IU/4000 IU: crucial for immune system health and bone health. Vitamin D helps with calcium absorption, and zinc supports cellular health and tissue regeneration.

Mega Omega-3: has anti-inflammatory properties and, together with zinc, can help reduce inflammation and support overall health.

Example: Skin and heart health supplements can combine zinc and omega-3 rich fish oil.

Probiotics: support digestive health, and zinc can help maintain a healthy intestinal mucosa, preventing inflammation and supporting immune function.

Ginkgo Max: Ginkgo Biloba can improve blood circulation and cognitive function, while zinc supports neuronal health and mental functioning. This combination may be beneficial for brain health and preventing cognitive decline.

Curcumin + Piperine 95%: Turmeric has strong anti-inflammatory properties thanks to curcumin, and zinc supports the immune system and cell regeneration. The combination can help reduce inflammation and support overall health.

Ashwagandha KSM-66 500 mg/700 mg: Ashwagandha is known for its adaptogenic properties, helping to reduce stress and improve energy. Zinc, in turn, supports mental health and immune function. Together, these supplements can help manage stress and support overall health.

Garlic Oil 1500 mg: Garlic has antimicrobial and anti-inflammatory properties. Combined with zinc, it can help support the immune system and fight infections.

Aloe Vera 5000 mg: Aloe Vera is known for its skin healing properties and supporting digestive health. Together with zinc, it can improve skin health and wound healing.

DOSE:

Adults: 1 capsule daily, preferably with meals.

Duration of Zinc Administration

The duration of zinc supplementation may vary depending on the purpose of use, the person’s health status, and the doctor’s recommendations.

1. Zinc Deficiency:
   • Duration: Supplementation may be necessary in the short term (a few weeks to a few months) until zinc levels return to normal. Your doctor will monitor your blood zinc levels and adjust your dosage accordingly.
   • Recommendation: It is essential to follow your doctor’s instructions and have regular blood tests to avoid toxicity.

2. Immune Support:
   • Duration: Supplementation can be used short-term during cold weather or when there is an increased risk of infection. Long-term use should be discussed with a doctor.
   • Recommendation: Small to moderate doses, as directed by your doctor.

3. Acne Treatment:
   • Duration: Can be taken for several months until improvements are seen. The exact duration will depend on the individual response to treatment.
   • Recommendation: Follow the instructions of the dermatologist.

4. Fertility:
   • Duration: Supplementation can be continued long-term if there are fertility problems, but should be monitored by a fertility specialist.
   • Recommendation: Periodic evaluation to adjust the dose as needed.

5. Improving physical performance:
   • Duration: Supplementation can be short-term during periods of intense training or competition. Consult a sports nutritionist for specific recommendations.
   • Recommendation: Make sure doses do not exceed recommended levels to avoid adverse effects.

6. General Use and Prevention:
   • Duration: Long-term supplementation shouldshould be monitored by a physician to avoid toxicity. It is usually recommended that the daily dose not exceed the recommended level of 40 mg for adults.
   • Recommendation: Supplement only if there is a clear justification and avoid high doses over the long term without medical supervision.

STORAGE CONDITIONS: at room temperature, away from light and moisture.

Does not contain: colorings, preservatives, artificial flavors, sugar, sodium, gluten/wheat, shellfish/fish, eggs, peanuts/nuts, soy, lactose.